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J Sleep Med > Volume 17(1); 2020 > Article
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J Sleep Med. 2020;17(1):1-10.         doi: https://doi.org/10.13078/jsm.200006
Narcolepsy, How do We Manage it?
Hyun-Woo Kim , Jae Wook Cho
Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea
Corresponding Author: Jae Wook Cho ,Tel: +82-55-360-2122, Fax: +82-55-360-2451, Email: sleepcho@pusan.ac.kr
Received: April 13, 2020   Revised: May 11, 2020   Accepted: May 13, 2020   Published online: June 30, 2020
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ABSTRACT
Narcolepsy is a chronic neurologic disorder characterized by excessive daytime sleepiness and cataplexy arising from dysregulation of pathway controlling the wake and sleep states. Despite advances in our understanding of the pathophysiology of narcolepsy, to date, only symptomatic treatments exist for this disease. Especially in Korea, only limited medication for narcolepsy has been available. In general, psychostimulants such as modafinil, armodafinil, and methylphenidate were prescribed to improve wakefulness, and cataplexy was managed with antidepressants. Recently many new agents has been developed and widely used in the United States and European countries. Some of those medications are expected to be available in Korea soon. Education of lifestyle modification and regular naps are also important strategy for the treatment of narcolepsy. This review summarizes briefly current and future medication, and nonpharmacological management of narcolepsy as well.
Keywords: Narcolepsy | Modafinil | Armodafinil | Pitolisant | Methylphenidate | Disorders of excessive somnolence
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