Objectives: This 52-week, double-blind, randomized, Phase 3 study evaluated the long-term safety of esmirtazapine 1.5 mg and 3.0 mg in elderly outpatients (aged ≥65 years) with insomnia.
Methods: Participants were randomized to receive esmirtazapine 1.5 mg or 3.0 mg administer...
Objectives: Rapid eye movement (REM) sleep without atonia (RSWA) fulfils one of the criteria for diagnosing REM sleep behavior disorder (RBD) according to the International Classification of Sleep Disorders, Third Edition. However, RSWA quantification is an unresolved issue, whi...
Objectives: Obstructive Sleep apnea (OSA) is characterized by complete or partial obstruction of upper airflow despite the effort to breathe, leading to hypoxemia and hypercapnia. The resultant apnea causes sleep fragmentation, which in turn increases sympathetic activity, decre...
Objectives: Bedtime procrastination is defined as going to bed later than intended, without having external reasons for doing so. According to previous studies, bedtime procrastination is strongly associated to usage of smart devices before bedtime. However, there is a lack of i...
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