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REVIEW ARTICLE
J Korean Sleep Res Soc. 2009;6(1):35-41.         doi: https://doi.org/10.13078/jksrs.09008
Mechanisms of obstructive sleep apnea development
Dae-wui Yoon, and Chol Shin
1Institute of Human Genomic Study, Korea University College of Medicine, Seoul, Korea
2Sleep Disorder Center, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
Corresponding Author: Chol Shin ,Tel: +82-31-412-5603, Fax: +82-31-412-5604, Email: chol-shin@hanmail.net
Received: 12 June 2009;  Accepted: 25 June 2009.
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ABSTRACT
Although obstructive sleep apnea (OSA) is a major public health problem, the pathogenesis of OSA is not fully understood. According to recent studies, development of OSA generally depends on the followings : (1) upper airway anatomy, (2) the ability of upper airway dilator muscle to respond to stimulation, (3) loop gain, (4) arousal threshold. These factors determine upper airway patency and ventilatory control stability. Thus, abnormalities in these systems lead to a narrowed, more collapsible pharyngeal airway and ventilator control instability, which lead in turn to development of OSA. OSA is a heterogeneous disorder which can develop as the result of a variety of physiologic characteristics, and may differently respond to therapeutic approaches based on the predominant abnormality. Therefore, the treatment of OSA must be individualized to the cause of the development of OSA.
Keywords: Obstructive sleep apnea | Upper airway | Loop gain | Arousal threshold | Ventilatory control stability
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