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REVIEW ARTICLE
J Korean Sleep Res Soc. 2005;2(1):16-20.         doi: https://doi.org/10.13078/jksrs.05003
Sleep and Endocrinology
Ho Won Lee, and Sung Pa Park
Department of Neurology, Kyungpook National University Hospital
Corresponding Author: Sung Pa Park ,Tel: +82-53-420-5769, Fax: +82-53-422-4265, Email: neuromd@mail.kun.ac.kr
Received: 5 June 2005;  Accepted: 15 June 2005.
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ABSTRACT
A bidirectional interaction between sleep electroencephalogram and endocrine activity is well established in humans. The studies suggest that various hormones (peptides and steroids) participate in sleep regulation. Growth hormone (GH)-releasing hormone (GHRH) stimulates GH and slow wave sleep (SWS), and inhibits cortisol, whereas corticotropin-releasing hormone (CRH) exerts opposite effects. Changes in the GHRH:CRH ratio contribute to sleep-endocrine aberrations during normal aging. In addition, galanin and neuropeptide Y promote sleep, whereas, in the elderly, somatostatin impairs sleep. In human vasoactive intestinal polypeptide appears to play a role in modulating rapid eye movement (REM)-nonREM cycle. Cortisol stimulates SWS and GH, probably by feedback inhibition of CRH. Neuroactive steroids exert specific effects on the sleep EEG.
Keywords: Sleep | Hormones | aging | HPS system | HPA system
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