| Sleep and Endocrinology |
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이호원, 박성파 |
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| Sleep and Endocrinology |
| Ho Won Lee, Sung Pa Park |
| Department of Neurology, Kyungpook National University Hospital |
| Corresponding Author:
Sung Pa Park ,Tel: +82-53-420-5769, Fax: +82-53-422-4265, Email: neuromd@mail.kun.ac.kr |
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Received: June 5, 2005 Accepted: June 15, 2005 Published online: June 30, 2005 |
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| ABSTRACT |
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A bidirectional interaction between sleep electroencephalogram and endocrine activity is well established in humans. The studies suggest that various hormones (peptides and steroids) participate in sleep regulation. Growth hormone (GH)-releasing hormone (GHRH) stimulates GH and slow wave sleep (SWS), and inhibits cortisol, whereas corticotropin-releasing hormone (CRH) exerts opposite effects. Changes in the GHRH:CRH ratio contribute to sleep-endocrine aberrations during normal aging. In addition, galanin and neuropeptide Y promote sleep, whereas, in the elderly, somatostatin impairs sleep. In human vasoactive intestinal polypeptide appears to play a role in modulating rapid eye movement (REM)-nonREM cycle. Cortisol stimulates SWS and GH, probably by feedback inhibition of CRH. Neuroactive steroids exert specific effects on the sleep EEG.
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| Keywords:
Sleep | Hormones | aging | HPS system | HPA system |
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