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REVIEW ARTICLE
J Korean Sleep Res Soc. 2008;5(1):26-32.         doi: https://doi.org/10.13078/jksrs.08004
Obstructive Sleep Apnea and Stroke; Cause or Consequence?
Yoski Kim, and Hyun-Young Park
Department of Neurology and Clinical Research Center, Wonkwang University, Iksan, Korea
Corresponding Author: Yoski Kim ,Tel: +82-63-859-1412, Fax: +82-63-842-7379, Email: yosik@wonkwang.ac.kr
Received: 5 June 2008;  Accepted: 25 June 2008.
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ABSTRACT
Obstructive sleep apnea (OSA) is a common disorder which noted in 2-4% of general population. Patients considered it as a non-significant event and do not try to evaluate and treat it. The common manifestation of OSA is related to sleep fragmentation and is an excessive daytime sleepiness, decreased concentration, memory impairment and decreased job activity. Furthermore, OSA has negative effects on cardiovascular system. It increases prevalence and incidence of stroke and ischemic heart disease. OSA is associated with early neurological worsening and delay recovery from neurological deficit after stroke. OSA has negative effects on hypertension, platelet activation, fibrinogen, cardiac arrhythmia, endothelial function and IMT (intima-media thickness) in carotid artery. Treatment with continuous positive airway pressure (CPAP) has demonstrated reduction in risk factor abnormality and hope to decrease risk of cardiovascular events including stroke. However, OSA has not been considered as an independent risk factor for stroke, it needs conclusive evidence from well designed epidemiological studies.
Keywords: Obstructive sleep apnea | Stroke | Positive airway pressure
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