| 수면 무호흡과 대사성 기능 부전(대사성 증후군) |
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허경 |
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연세대학교 의과대학 신경과학교실 |
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| Sleep Apnea and Metabolic Dysfunction(Metabolic Syndrome) |
| Kyoung Heo |
| Department of Neurology, Yonsei University College of Medicine |
| Corresponding Author:
Kyoung Heo ,Tel: +82-2-2228-1607, Fax: +82-2-393-0705, Email: kheo@yuhs.ac |
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Received: June 5, 2007 Accepted: June 24, 2007 Published online: June 30, 2007 |
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| ABSTRACT |
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The metabolic syndrome represents a clustering of several interrelated risk factors of metabolic origin that are thought to increase
cardiovascular risk. One metabolic abnormality that may underlie several clinical characteristics of the metabolic syndrome is insulin
resistance. The evidence that obstructive sleep apnea may independently lead to the development of both insulin resistance and individual
clinical components of the metabolic syndrome, has been accumulated. Continuous positive airway pressure treatment for sleep apnea
may be helpful for improvement of metabolic syndrome although the evidence is still insufficient. Intermittent hypoxemia and sleep
fragmentation in sleep apnea can trigger a cascade of pathophysiological events, including autonomic activation, alterations in
neuroendocrine function, and release of potent proinflammatory mediators such as tumor necrosis factor-α and interleukin-6. The converse
may also be true, in that metabolic abnormalities associated with the metabolic syndrome and insulin resistance may potentially exacerbate
sleep apnea and daytime sleepiness. The notion that sleep apnea exert detrimental metabolic effects may help explain the increasing
prevalence of the metabolic syndrome and insulin resistance in the general population, and may have important therapeutic implications
to combat the metabolic and cardiovascular disease.
Key Words : Obstructive sleep apnea, Metabolic syndrome, Insulin resistance |
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