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J Korean Sleep Res Soc. 2006;3(2):102-106.         doi: https://doi.org/10.13078/jksrs.06018
Obstructive Sleep Apnea Syndrome Associated with Acromegaly
Jeong Lee, Choong-Kun Ha, and Chang-Ho Yun
Department of Neurology, College of Medicine, Inha University. Incheon
Corresponding Author: Chang-Ho Yun ,Tel: +82-32-890-3418, 386, Fax: +82-32-890-3864, Email: ych333@inha.ac.kr
Received: 4 December 2006;  Accepted: 24 December 2006.
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Acromegaly can cause obstructive sleep apnea syndrome because excessive growth hormone (GH) results in abnormal growth of craniofacial skeleton and parapharyngeal soft tissue. A 46-year-old female patient presented with excessive daytime sleepiness and habitual snoring. Polysomnography and multiple sleep latency test documented moderate to severe degree of obstructive sleep-disordered breathings and excessive daytime sleepiness. Craniofacial characteristics leaded to the endocrinologic study that confirmed excessive GH secretion. Sella magnetic resonance image revealed underlying pituitary macroadenoma. Craniofacial features should be carefully evaluated to find the underlying cause of obstructive sleep apnea.
Keywords: Acromegaly | Obstructive sleep apnea syndrome | Pituitary macroadenoma
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