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REVIEW ARTICLE
J Korean Sleep Res Soc. 2005;2(1):1-9.         doi: https://doi.org/10.13078/jksrs.05001
Basic Principles of Chronobiology
Sang Ahm Lee
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine
Corresponding Author: Sang Ahm Lee ,Tel: +82-2-3010-3440, Fax: +82-2-474-4691, Email: salee@amc.seoul.kr
Received: 21 April 2005;  Accepted: 12 June 2005.
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ABSTRACT
This review is focusing on circadian aspects of chronobiology. The human sleep-wake cycle is generated by a circadian process, originating from the suprachiasmatic nuclei, in interaction with a separate oscillatory process, that is, the sleep homeostasis. The sleep-wake cycle is normally timed to occur at a specific phase relative to internal circadian rhythms as well as the external cycle of light-dark exposure. Consideration of both external and internal sleep timing may provide new parameters to quantify the phenomenology of normal and abnormal sleep regulation. Changes in ocular photoreception, interindividual variation in the near-24-h intrinsic period of the endogenous circadian pacemaker, and sleep homeostasis can contribute to variations in external and internal phase. Recent developments, deriving directly from animal work in molecular chronobiology, portend a transformation in our view of circadian rhythm sleep disorders. In conclusion, chronobiology now has a central and vital role in modern sleep disorders medicine.
Keywords: Sleep | Circadian rhythms | Sleep-wake cycle | Chronobiology | Sleep homeostasis | Entrainment
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