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REVIEW ARTICLE
J Korean Sleep Res Soc. 2006;3(1):6-10.         doi: https://doi.org/10.13078/jksrs.06002
Neurobiology of Sleep-Wake Control
Yong-Won Cho
Department of Neurology, College of Medicine, Keimyung University, Daegu, Korea
Corresponding Author: Yong-Won Cho ,Tel: +82-53-250-7831, Fax: +82-53-250-7840, Email: neurocho@dsmc.or.kr
Received: 1 May 2006;  Accepted: 19 May 2006.
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ABSTRACT
The regulations of sleep-wake cycle is complicated and many neurochemicals are involved. It is the consequence of an active process requiring appropriate interactions ofbrainstem and the cerebral system. The homeostatic drive and circadian factors are major controls in this regulation. The reticular activation system is a wake promoting area and the neurons in pons and preoptic areas are involved in non-rapid eye movement sleep and rapid eye movement sleep. Sleep is a necessary behavior and it is, at least in part, a restorative process. Good sleep during the nightis important for a healthy condition during the day time. Understanding of these reciprocal sleep-wake interactions should be very important to better understand the effects of many drugs and many other sleep related diseases.
Keywords: sleep | arousal | neurobiology
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