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J Korean Sleep Res Soc > Volume 2(2); 2005 > Article
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J Korean Sleep Res Soc. 2005;2(2):41-43.         doi: https://doi.org/10.13078/jksrs.05015
Episodic diencephalic hypoperfusion in Kleine-Levin syndrome
Eun Yeon Joo, Woo Suk Tae, Sun Jung Han, Sun Wha Kim, Sung-Ik Lee, Seung Bong Hong
1Department of Neurology, Samsung Medical Center and Center for Clinical Medicine, SBRI, Sungkyunkwan University School of Medicine, Seoul
2Department of Neurology, San-bon Won Kwang University hospital, Kumpo, Korea
Corresponding Author: Seung Bong Hong ,Tel: +82-2-3410-3592, Fax: +82-2-3410-0052, Email: sbhong@smc.samsung.co.kr
Received: November 16, 2005   Accepted: December 23, 2005   Published online: December 31, 2005
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ABSTRACT
We report a 24 year-old woman presenting with recurrent episodes of hypersomnia, apathy, personality changes, irritability and hyperphagia since February 2001. Brain single photon emission computed tomography (SPECT) was performed during symptomatic and asymptomatic periods, respectively and then subtracted ictal SPECT coregistered to MRI (SISCOM) was done between those two SPECT images. Interictal brain SPECT suggested suspicious hypoperfusion in right mesial temporal region whereas ictal SPECT showed hypoperfusion in bilateral frontal and temporal lobes, and thalami/hypothalami. SISCOM showed significantly decreased perfusion in thalamus/hypothalamus and frontotemporal regions during a symptomatic period.
Keywords: Kleine-Levin syndrome | SPECT | Thalamus | Hypothalamus | Hypersomniar
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